What it does: Citrulline helps increase nitric oxide levels, which widens blood vessels for improved circulation and oxygen delivery to muscles, supporting physical performance and muscle recovery.
How it is used: It is frequently taken in pre-workout and endurance supplements to support muscle endurance, reduce exercise fatigue, and enhance blood flow during workouts.
Natural sources and supplement forms: Watermelon and some other fruits contain citrulline naturally. Supplement forms include L-citrulline and citrulline malate, available as powders or capsules.
Why it appears in supplement formulas: Brands add citrulline to support enhanced exercise capacity, better muscular performance, and improved recovery for people interested in fitness and sports.
What to know before use: Citrulline is generally safe for healthy adults, but those with kidney issues or using blood pressure medications should consult a healthcare provider before supplementing.
Citrulline: A Watermelon-Derived Amino Acid
Citrulline is a naturally occurring amino acid first discovered in watermelon, which is one of the richest sources in nature. In the body, citrulline is involved in the urea cycle—a process that helps remove excess ammonia—making it a unique nutrient often included in supplements targeted for active lifestyles.
